WS-T 777-2021 化学物质环境健康风险评估技术指南

ICS 13.020 CCS C 51 中华人民共和国卫生行业标准 WS/T 777—2021 ws 化学物质环境健康风险评估技术指南 Technical guide for environmental health risk assessment of chemical exposure 2021 - 03 - 29发布 2021 - 03 - 29实施中华人民共和国国家卫生健康委员会发布 WS/T 777 —2021 I 目次前言 ................................ ................................ ................ III 1 范围 ................................ ................................ ............... 1 2 规范性引用文件 ................................ ................................ ..... 1 3 术语和定义 ................................ ................................ ......... 1 4 需考虑的因素 ................................ ................................ ....... 2 4.1评估任务 ................................ ................................ ......... 2 4.2健康效应 ................................ ................................ ......... 2 4.3暴露途径 ................................ ................................ ......... 2 5 评估内容与流程 ................................ ................................ ..... 2 5.1评估内容 ................................ ................................ ......... 2 5.2评估流程 ................................ ................................ ......... 2 6 危害识别 ................................ ................................ ........... 3 6.1健康危害识别 ................................ ................................ ..... 4 6.2暴露信息获取 ................................ ................................ ..... 4 6.3评估启动判定 ................................ ................................ ..... 4 7 剂量—反应评估 ................................ ................................ ..... 4 7.1剂量—反应关系参数确认 ................................ ........................... 4 7.1.1非致癌效应 ................................ ................................ ... 4 7.1.2致癌效应 ................................ ................................ ..... 4 7.2剂量—反应关系参数检索 ................................ ........................... 4 7.3剂量—反应关系参数估算 ................................ ........................... 4 7.3.1剂量—反应关系参数推导 ................................ ....................... 5 7.3.2剂量—反应关系参数不确定性 ................................ ................... 6 7.4剂量—反应关系参数汇总 ................................ ........................... 6 8 暴露评估 ................................ ................................ ........... 6 8.1暴露途径及浓度评估 ................................ ............................... 6 8.1.1暴露途径分析 ................................ ................................ . 6 8.1.2暴露浓度评估 ................................ ................................ . 6 8.1.3浓度信息整合 ................................ ................................ . 6 8.2暴露参数获取 ................................ ................................ ..... 7 8.2.1暴露参数 ................................ ................................ ..... 7 8.2.2暴露参数获取途径 ................................ ............................. 7 8.3暴露量评估 ................................ ................................ ....... 7 8.3.1经口摄入途径的暴露量评估 ................................ ..................... 7 8.3.2吸入途径的暴露量评估 ................................ ......................... 8 8.3.3皮肤接触途径的暴露量评估 ................................ ..................... 9 8.4暴露量信息汇总 ................................ ................................ .. 10 9 风险表征 ................................ ................................ .......... 10 WS/T 777 —2021 II 9.1风险定量 ................................ ................................ ........ 10 9.1.1非致癌风险 ................................ ................................ .. 10 9.1.2致癌风险 ................................ ................................ .... 10 9.2风险加和 ................................ ................................ ........ 12 9.2.1风险加和原则 ................................ ................................ 12 9.2.2非致癌风险加和 .......