论文标题
使用体积光学相干断层扫描图像的高速无标记组织运动跟踪
High-Speed Markerless Tissue Motion Tracking Using Volumetric Optical Coherence Tomography Images
论文作者
论文摘要
现代的光学相干断层扫描（OCT）设备提供具有千分尺尺度空间分辨率和超出视频速率的时间分辨率的体积图像。在这项工作中，我们分析了一个基于OCT的原型跟踪系统，该系统每秒处理831卷，估算转换运动，并自动调整视野的尺寸，该视野的大小为少数毫米，以沿较大距离遵循样品。调整由两个Galvo镜和一个电动参考臂实现，因此扫描设置无需机械运动。在不需要标记或任何其他有关样品的知识的情况下，我们证明了最高25 mm/s的可靠跟踪，而平均跟踪误差为0.25 mm。此外，我们报告了对高达70 mm/s的横向速度的成功跟踪，误差低于0.3 mm。
Modern optical coherence tomography (OCT) devices provide volumetric images with micrometer-scale spatial resolution and a temporal resolution beyond video rate. In this work, we analyze an OCT-based prototypical tracking system which processes 831 volumes per second, estimates translational motion, and automatically adjusts the field-of-view, which has a size of few millimeters, to follow a sample even along larger distances. The adjustment is realized by two galvo mirrors and a motorized reference arm, such that no mechanical movement of the scanning setup is necessary. Without requiring a marker or any other knowledge about the sample, we demonstrate that reliable tracking of velocities up to 25 mm/s is possible with mean tracking errors in the order of 0.25 mm. Further, we report successful tracking of lateral velocities up to 70 mm/s with errors below 0.3 mm.
