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We present a coherent and consistent framework for explicit time-dependence in non-Hermitian quantum mechanics. The area of non-Hermitian quantum mechanics has been growing rapidly over the past twenty years. This has been driven by the fact that $\mathcal{PT}$-symmetric non-Hermitian systems exhibit real energy eigenvalues and unitary time evolution. Historically, the introduction of time into the world of non-Hermitian quantum mechanics has been a conceptually difficult problem to address, as it requires the Hamiltonian to become unobservable. We solve this issue with the introduction of a new observable energy operator and explain why its instigation is a necessary and natural progression in this setting. For the first time, the introduction of time has allowed us to make sense of the parameter regime in which the $\mathcal{PT}$-symmetry is spontaneously broken. Ordinarily, in the time-independent setting, the energy eigenvalues become complex and the wave functions are asymptotically unbounded. We demonstrate that in the time-dependent setting this broken symmetry can be mended and analysis on the spontaneously broken $\mathcal{PT}$ regime is indeed possible. We provide many examples of this mending on a wide range of different systems, beginning with a $2\times2$ matrix model and extending to higher dimensional matrix models and coupled harmonic oscillator systems with infinite Hilbert space. Furthermore, we use the framework to perform analysis on time-dependent quasi-exactly solvable models. We present the "eternal life" of entropy in this thesis. Ordinarily, for entangled quantum systems coupled to the environments, the entropy decays rapidly to zero. However, in the spontaneously broken regime, we find the entropy decays asymptotically to a non-zero value. We create an elegant framework for Darboux and Darboux/Crum transformations for time-dependent non-Hermitian Hamiltonians.