论文标题
在工作记忆的中央执行功能中的抑制和设定转移任务：与事件相关的潜力（ERP）研究
Inhibition and Set-Shifting Tasks in Central Executive Function of Working Memory: An Event-Related Potential (ERP) Study
论文作者
论文摘要
了解复杂的更高认知过程的神经动力学，工作记忆（WM）具有挑战性。在WM中，信息处理通过四个子系统进行：语音循环，视觉素描垫，内存缓冲区和中央执行功能（CEF）。 CEF在WM中起主要作用。在这项研究中，我们的目标是了解抑制和设置转移过程中CEF的神经空间相关性。选择了30名健康的受过教育的科目。使用32通道脑电图系统收集了与视觉抑制和设置转移任务有关的事件相关电位（ERP）。使用正峰和负峰的振幅分析了这些ERP成分的激活。基于平均反应，使用某些参数限制来控制实验，以建立ERP与脑激活的局部关系之间的关系，并使用标准化的低分辨率脑电磁断层扫描表示。与设置变动任务相比，抑制任务的平均得分（87.5％）更高（87.5％）（59.5％）。与额叶中心区域中的设置转移任务相比，用于抑制任务的神经元活性的峰值幅度较低。因此，该提出的范式和技术可用于测量神经精神疾病患者病理中心执行功能的抑制和固定转变神经元过程。
Understanding of neuro-dynamics of a complex higher cognitive process, Working Memory (WM) is challenging. In WM, information processing occurs through four subsystems: phonological loop, visual sketch pad, memory buffer and central executive function (CEF). CEF plays a principal role in WM. In this study, our objective was to understand the neurospatial correlates of CEF during inhibition and set-shifting processes. Thirty healthy educated subjects were selected. Event-Related Potential (ERP) related to visual inhibition and set-shifting task was collected using 32 channel EEG system. Activation of those ERPs components was analyzed using amplitudes of positive and negative peaks. Experiment was controlled using certain parametric constraints to judge behavior, based on average responses in order to establish relationship between ERP and local area of brain activation and represented using standardized low resolution brain electromagnetic tomography. The average score of correct responses was higher for inhibition task (87.5%) as compared to set-shifting task (59.5%). The peak amplitude of neuronal activity for inhibition task was lower compared to set-shifting task in fronto-parieto-central regions. Hence this proposed paradigm and technique can be used to measure inhibition and set-shifting neuronal processes in understanding pathological central executive functioning in patients with neuro-psychiatric disorders.
