论文标题

神经场模型的数值研究包括树突状处理

Numerical investigation of a neural field model including dendritic processing

论文作者

Avitabile, Daniele, Coombes, Stephen, Lima, Pedro M.

论文摘要

我们考虑了一个简单的神经场模型,其中状态变量是树突电压,其中躯体形成连续的一维层。这种具有树突加工的神经场模型被表达为一个差异方程。我们引入了一种将解决方案近似于该非局部模型的计算方法,并使用它来对神经生物学上的解剖连通性和非线性触发速率函数进行数值模拟。在时间离散时,我们采用隐式解释(IMEX)方案;空间离散化基于有限差分方案,以近似扩散项,并使用梯形规则来近似描述模型中非局部相互作用的积分。我们证明该方案在时间上是一阶和空间中的二阶,并且如果预先计算小型矩阵的分解,则可以有效地实现。通过验证,我们将数值实现的输出与图灵模式发作的理论预测以及行进前沿的速度和形状进行比较,以选择重质射击速率。我们发现理论和数值模拟非常同意。

We consider a simple neural field model in which the state variable is dendritic voltage, and in which somas form a continuous one-dimensional layer. This neural field model with dendritic processing is formulated as an integro-differential equation. We introduce a computational method for approximating solutions to this nonlocal model, and use it to perform numerical simulations for neuro-biologically realistic choices of anatomical connectivity and nonlinear firing rate function. For the time discretisation we adopt an Implicit-Explicit (IMEX) scheme; the space discretisation is based on a finite-difference scheme to approximate the diffusion term and uses the trapezoidal rule to approximate integrals describing the nonlocal interactions in the model. We prove that the scheme is of first-order in time and second order in space, and can be efficiently implemented if the factorisation of a small, banded matrix is precomputed. By way of validation we compare the outputs of a numerical realisation to theoretical predictions for the onset of a Turing pattern, and to the speed and shape of a travelling front for a specific choice of Heaviside firing rate. We find that theory and numerical simulations are in excellent agreement.

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