论文标题
随机旋转电动机的随机旋转电动机中的非平衡能量转导
Nonequilibrium Energy Transduction in Stochastic Strongly Coupled Rotary Motors
论文作者
论文摘要
分子量表的生活系统由许多具有较强和异质相互作用的成分组成，远非平衡，并且会受到强烈的波动。这些条件对有效，精确和快速的自由能转导构成了重大挑战，但自然已经发展了许多这样做的分子机器。使用巧妙的旋转机FOF1-ATP合酶的简单模型，我们研究了非平衡驱动力，热波动和强耦合子系统之间的相互作用之间的相互作用。该模型揭示了有效的自由能传输的设计原理。最值得注意的是，虽然紧密的耦合具有直观的吸引力，但我们发现，中等强度耦合的输出功率最大化，这允许仅通过最小滑移而通过随机波动进行润滑。
Living systems at the molecular scale are composed of many constituents with strong and heterogeneous interactions, operating far from equilibrium, and subject to strong fluctuations. These conditions pose significant challenges to efficient, precise, and rapid free energy transduction, yet nature has evolved numerous molecular machines that do just this. Using a simple model of the ingenious rotary machine FoF1-ATP synthase, we investigate the interplay between nonequilibrium driving forces, thermal fluctuations, and interactions between strongly coupled subsystems. This model reveals design principles for effective free energy transduction. Most notably, while tight coupling is intuitively appealing, we find that output power is maximized at intermediate-strength coupling, which permits lubrication by stochastic fluctuations with only minimal slippage.
