论文标题
一种研究高度感染性疾病传播的发作的微观方法
A microscopic approach to study the onset of a highly infectious disease spreading
论文作者
论文摘要
我们将行人动力学模型与接触追踪方法相结合,以模拟在密闭环境中高度感染的空中疾病的初始扩散。我们专注于中等大小的人口(最多1000人),其中少数传染性人(1或2),其余的人在免疫和易感性之间分配。我们采用一个空间连续模型,该模型代表作用于它们的力,即基于微观力量的模型。一旦离散化,该模型就会产生二阶普通微分方程的高维系统。在将接触跟踪添加到行人动力学模型中之前,我们对模型参数进行校准,根据经验数据验证模型,并表明可以捕获行人自组织到泳道中。我们考虑通过在病人周围引入疾病领域来进行接触追踪的明确方法。一个健康但易感性的人,他在一定的时间内留在疾病领域,可能会感染(规定的概率),并成为所谓的次要接触。作为模拟疾病传播发作的具体环境,我们考虑了两个美国机场的航站楼:休斯敦的爱好机场和亚特兰大国际机场。我们考虑不同的情况,并且随着给定末端的人口更密集,免疫人员的百分比减少,主要接触的数量增加,高密度(例如寄宿总线)的区域增加,二次接触的平均数量增加增加,免疫人员的百分比增加。
We combine a pedestrian dynamics model with a contact tracing method to simulate the initial spreading of a highly infectious airborne disease in a confined environment. We focus on a medium size population (up to 1000 people) with a small number of infectious people (1 or 2) and the rest of the people is divided between immune and susceptible. We adopt a space-continuous model that represents pedestrian dynamics by the forces acting on them, i.e. a microscopic force-based model. Once discretized, the model results in a high-dimensional system of second order ordinary differential equations. Before adding the contact tracing to the pedestrian dynamics model, we calibrate the model parameters, validate the model against empirical data, and show that pedestrian self-organization into lanes can be captured. We consider an explicit approach for contact tracing by introducing a sickness domain around a sick person. A healthy but susceptible person who remains in the sickness domain for a certain amount of time may get infected (with a prescribed probability) and become a so-called secondary contact. As a concrete setting to simulate the onset of disease spreading, we consider terminals in two US airports: Hobby Airport in Houston and the Atlanta International Airport. We consider different scenarios and we quantify the increase in average number of secondary contacts increases as a given terminal becomes more densely populated, the percentage of immune people decreases, the number of primary contacts increases, and areas of high density (such as the boarding buses) are present.