论文标题
从IMU数据中检测帕金森尼震颤
Detecting Parkinsonian Tremor from IMU Data Collected In-The-Wild using Deep Multiple-Instance Learning
论文作者
论文摘要
帕金森氏病(PD)是一种缓慢发展的神经逻辑疾病,影响了大约1%以上60岁以上的人群,导致症状最初微妙,但其强度随着疾病的发展而增加。这些症状的自动检测可以提供有关疾病早期发作的线索,从而通过适当的靶向干预措施改善了患者的预期临床结果。这种潜力导致许多研究人员开发了使用广泛可用的传感器来测量和量化PD症状(例如震颤,僵化和Braykinesia)的方法。但是,这些方法中的大多数在受控设置(例如在实验室或在家中)运行,从而限制了它们在自由生活条件下的适用性。在这项工作中,我们提出了一种基于通过智能手机设备捕获的IMU信号自动识别与PD相关的颤抖的方法。我们提出了一种多种稳定学习方法,其中一个受试者表示为无序的加速度计信号段和一个专家提供的震颤注释。我们的方法将深入的功能学习与可学习的汇总阶段相结合,该阶段能够识别主题包中的关键实例,同时仍然是可训练的端到端。我们在新引入的45个受试者的数据集上验证了我们的算法,其中包含完全在野外收集的加速度计信号。在执行实验中获得的良好分类性能表明,所提出的方法可以有效地浏览野外记录的嘈杂环境。
Parkinson's Disease (PD) is a slowly evolving neuro-logical disease that affects about 1% of the population above 60 years old, causing symptoms that are subtle at first, but whose intensity increases as the disease progresses. Automated detection of these symptoms could offer clues as to the early onset of the disease, thus improving the expected clinical outcomes of the patients via appropriately targeted interventions. This potential has led many researchers to develop methods that use widely available sensors to measure and quantify the presence of PD symptoms such as tremor, rigidity and braykinesia. However, most of these approaches operate under controlled settings, such as in lab or at home, thus limiting their applicability under free-living conditions. In this work, we present a method for automatically identifying tremorous episodes related to PD, based on IMU signals captured via a smartphone device. We propose a Multiple-Instance Learning approach, wherein a subject is represented as an unordered bag of accelerometer signal segments and a single, expert-provided, tremor annotation. Our method combines deep feature learning with a learnable pooling stage that is able to identify key instances within the subject bag, while still being trainable end-to-end. We validate our algorithm on a newly introduced dataset of 45 subjects, containing accelerometer signals collected entirely in-the-wild. The good classification performance obtained in the conducted experiments suggests that the proposed method can efficiently navigate the noisy environment of in-the-wild recordings.