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The advent of a new generation of large-scale galaxy surveys is pushing cosmological numerical simulations in an uncharted territory. The simultaneous requirements of high resolution and very large volume pose serious technical challenges, due to their computational and data storage demand. In this paper, we present a novel approach dubbed Dynamic Zoom Simulations -- or DZS -- developed to tackle these issues. Our method is tailored to the production of lightcone outputs from N-body numerical simulations, which allow for a more efficient storage and post-processing compared to standard comoving snapshots, and more directly mimic the format of survey data. In DZS, the resolution of the simulation is dynamically decreased outside the lightcone surface, reducing the computational work load, while simultaneously preserving the accuracy inside the lightcone and the large-scale gravitational field. We show that our approach can achieve virtually identical results to traditional simulations at half of the computational cost for our largest box. We also forecast this speedup to increase up to a factor of 5 for larger and/or higher-resolution simulations. We assess the accuracy of the numerical integration by comparing pairs of identical simulations run with and without DZS. Deviations in the lightcone halo mass function, in the sky-projected lightcone, and in the 3D matter lightcone always remain below 0.1%. In summary, our results indicate that the DZS technique may provide a highly-valuable tool to address the technical challenges that will characterise the next generation of large-scale cosmological simulations.