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Modern large-scale systems such as recommender system and online advertising system are built upon computation-intensive infrastructure. The typical objective in these applications is to maximize the total revenue, e.g. GMV~(Gross Merchandise Volume), under a limited computation resource. Usually, the online serving system follows a multi-stage cascade architecture, which consists of several stages including retrieval, pre-ranking, ranking, etc. These stages usually allocate resource manually with specific computing power budgets, which requires the serving configuration to adapt accordingly. As a result, the existing system easily falls into suboptimal solutions with respect to maximizing the total revenue. The limitation is due to the face that, although the value of traffic requests vary greatly, online serving system still spends equal computing power among them. In this paper, we introduce a novel idea that online serving system could treat each traffic request differently and allocate "personalized" computation resource based on its value. We formulate this resource allocation problem as a knapsack problem and propose a Dynamic Computation Allocation Framework~(DCAF). Under some general assumptions, DCAF can theoretically guarantee that the system can maximize the total revenue within given computation budget. DCAF brings significant improvement and has been deployed in the display advertising system of Taobao for serving the main traffic. With DCAF, we are able to maintain the same business performance with 20\% computation resource reduction.