论文标题

具有扩散和层流的圆柱MC通道的传输功能模型

Transfer Function Models for Cylindrical MC Channels with Diffusion and Laminar Flow

论文作者

Schäfer, Maximilian, Wicke, Wayan, Brand, Lukas, Rabenstein, Rudolf, Schober, Robert

论文摘要

在圆柱环境中基于对流扩散的分子通信(MC)系统的分析和设计对于诸如微流体学和血管中的靶向药物递送等应用特别感兴趣。因此,相应的MC通道的准确建模非常重要。这些系统中粒子的传播是由扩散和流动与抛物线速度曲线(即层流流的结合)的组合引起的。颗粒的传播特征可以分为三种不同的状态:流动主导性的扩散对粒子传输的影响可忽略不计,扩散具有比流动更强大的分散状态,以及两种影响都很重要的混合状态。对于限制机制,即流动主导和分散性机制,有众所周知的解决方案和粒子传输的近似值。相比之下,没有用于混合制度的一般分析解决方案,而是采用了近似值,数值技术和基于粒子的模拟。在本文中,我们为圆​​柱环境中的对流扩散问题开发了一个通用模型,该模型提供了适用于所有制度的分析解决方案。建模过程基于传输函数方法,主要重点在于将层流的融合到分析模型中。通过数值评估对不同场景的数值评估进行分析,包括粒子的均匀和点释放。我们提供了基于粒子的模拟和限制模式的众所周知的解决方案的比较,以证明所提出的分析模型的有效性。

The analysis and design of advection-diffusion based molecular communication (MC) systems in cylindrical environments is of particular interest for applications such as micro-fluidics and targeted drug delivery in blood vessels. Therefore, the accurate modeling of the corresponding MC channel is of high importance. The propagation of particles in these systems is caused by a combination of diffusion and flow with a parabolic velocity profile, i.e., laminar flow. The propagation characteristics of the particles can be categorized into three different regimes: The flow dominant regime where the influence of diffusion on the particle transport is negligible, the dispersive regime where diffusion has a much stronger impact than flow, and the mixed regime where both effects are important. For the limiting regimes, i.e., the flow dominant and dispersive regimes, there are well-known solutions and approximations for particle transport. In contrast, there is no general analytical solution for the mixed regime, and instead, approximations, numerical techniques, and particle based simulations have been employed. In this paper, we develop a general model for the advection-diffusion problem in cylindrical environments which provides an analytical solution applicable in all regimes. The modeling procedure is based on a transfer function approach and the main focus lies on the incorporation of laminar flow into the analytical model. The properties of the proposed model are analyzed by numerical evaluation for different scenarios including the uniform and point release of particles. We provide a comparison with particle based simulations and the well-known solutions for the limiting regimes to demonstrate the validity of the proposed analytical model.

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