论文标题
微流体芯片的趋化性多域传输模型的质量保护近似
Mass-preserving approximation of a chemotaxis multi-domain transmission model for microfluidic chips
论文作者
论文摘要
本工作的灵感来自于在芯片上进行的实验室实验的最新发展，在这种实验实验中，可以培养多种细胞物种。该模型基于与趋化性的耦合反应扩散 - 传输方程，并考虑了细胞种群之间的相互作用以及药物给药的可能性。我们的努力致力于开发一个能够重现趋化运动以及生活在微流体芯片环境中的不同细胞（免疫和癌细胞）之间的相互作用的模拟工具。这项工作中面临的主要问题是引入质量保护和积极性的条件，涉及通过芯片的2D和1D域之间的接口以及在外部边界和接口之间以及在2D和1D domains之间的数值保存的界面之间的界面以及质量阳性和积极性的发展。
The present work was inspired by the recent developments in laboratory experiments made on chip, where culturing of multiple cell species was possible. The model is based on coupled reaction-diffusion-transport equations with chemotaxis, and takes into account the interactions among cell populations and the possibility of drug administration for drug testing effects. Our effort was devoted to the development of a simulation tool that is able to reproduce the chemotactic movement and the interactions between different cell species (immune and cancer cells) living in microfluidic chip environment. The main issues faced in this work are the introduction of mass-preserving and positivity-preserving conditions involving the balancing of incoming and outgoing fluxes passing through interfaces between 2D and 1D domains of the chip and the development of mass-preserving and positivity preserving numerical conditions at the external boundaries and at the interfaces between 2D and 1D domains.
