论文标题
突触DMC的受体饱和建模
Receptor Saturation Modeling for Synaptic DMC
论文作者
论文摘要
突触通信是一种天然分子通信(MC)系统,可以用作合成MC系统设计的蓝图。特别是,它具有高度专业的机制,可以实现符号间干扰(ISI) - 无和节能的通信。在脑机界面的背景下,对突触MC的理解对于破坏性创新至关重要。然而,突触MC的物理模型由于神经递质的突触后受体的竞争而引起的分子接收器可能饱和,使突触MC的物理建模变得复杂。饱和度会导致系统行为非线性,并且在现有分析模型中通常被忽略。在这项工作中,我们提出了一个新型的受体饱和模型,该模型是针对Fick扩散方程的非线性,状态依赖性边界条件的。我们使用拉普拉斯操作员的本本特征功能扩展以及将接收器存储器作为反馈系统纳入相应的状态空间描述来解决所得的边界值问题。提出的解决方案在数值上是稳定的,并且在计算上有效。此外,提出的模型通过基于粒子的随机计算机模拟验证。
Synaptic communication is a natural Molecular Communication (MC) system which may serve as a blueprint for the design of synthetic MC systems. In particular, it features highly specialized mechanisms to enable inter-symbol interference (ISI)-free and energy efficient communication. The understanding of synaptic MC is furthermore critical for disruptive innovations in the context of brain-machine interfaces. However, the physical modeling of synaptic MC is complicated by the possible saturation of the molecular receiver arising from the competition of postsynaptic receptors for neurotransmitters. Saturation renders the system behavior nonlinear and is commonly neglected in existing analytical models. In this work, we propose a novel model for receptor saturation in terms of a nonlinear, state-dependent boundary condition for Fick's diffusion equation. We solve the resulting boundary-value problem using an eigenfunction expansion of the Laplace operator and the incorporation of the receiver memory as feedback system into the corresponding state-space description. The presented solution is numerically stable and computationally efficient. Furthermore, the proposed model is validated with particle-based stochastic computer simulations.