论文标题
旨在解码癌症中代谢和上皮 - 间质转变的耦合决策
Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer
论文作者
论文摘要
癌细胞具有调节其代谢表型以生存和转移的可塑性。在转移期间，一个称为上皮 - 间质转变（EMT）的发展程序起着至关重要的作用。新陈代谢和EMT之间存在广泛的跨话，但是这如何导致协调的生理变化仍然不确定。代谢和EMT之间的难以捉摸的联系损害了靶向转移的代谢疗法的功效。在这篇综述中，我们旨在根据最新的实验研究阐明代谢和EMT之间的因果关系，并提出综合的理论实验努力，以更好地了解代谢和EMT的耦合决策。
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive cross-talk between metabolism and EMT, but how this leads to coordinated physiological changes is still uncertain. The elusive connection between metabolism and EMT compromises the efficacy of metabolic therapies targeting metastasis. In this review, we aim for clarifying causation between metabolism and EMT based on recent experimental studies and propose integrated theoretical-experimental efforts to better understand the coupled decision-making of metabolism and EMT.
