论文标题
使用标签不确定性的3D到2D网络对肿瘤核分割的不确定性驱动式细化
Uncertainty-driven refinement of tumor-core segmentation using 3D-to-2D networks with label uncertainty
论文作者
论文摘要
Brats数据集包含高级和低级神经胶质瘤的混合物,这些混合物的外观截然不同:先前的研究表明,通过对低度胶质瘤(LGGS)和高级神经胶质瘤(HGGS)进行分离的培训可以改善性能,但是实际上,实际上该信息在测试时间不可用。与HGG相比,LGG通常在肿瘤核与周围水肿之间没有尖锐的边界,而是肿瘤细胞密度的逐渐减小。 利用我们的3D到2D完全卷积的体系结构DeepScan在2019年的Brats挑战中排名很高,并使用不确定性感知的损失进行了训练,我们将案例分离为那些有肯定分段的核心的案例,以及那些模糊分段或缺失核心的情况。由于通过假设每个肿瘤都有一个核心,因此在核心组织分割的情况下,我们会模糊地定义或缺少核心组织分类的阈值。 然后,我们使用线性回归和随机森林分类的融合来预测高级神经胶质瘤患者的存活,该融合基于年龄,不同的肿瘤成分的数量以及不同肿瘤核的数量。 我们介绍了2020年多模式脑肿瘤分割挑战的验证数据集(分割和不确定性挑战),以及在测试集中,该方法在分割中获得第4位,不确定性估计中的第一名,而在生存预测中获得了第一名。
The BraTS dataset contains a mixture of high-grade and low-grade gliomas, which have a rather different appearance: previous studies have shown that performance can be improved by separated training on low-grade gliomas (LGGs) and high-grade gliomas (HGGs), but in practice this information is not available at test time to decide which model to use. By contrast with HGGs, LGGs often present no sharp boundary between the tumor core and the surrounding edema, but rather a gradual reduction of tumor-cell density. Utilizing our 3D-to-2D fully convolutional architecture, DeepSCAN, which ranked highly in the 2019 BraTS challenge and was trained using an uncertainty-aware loss, we separate cases into those with a confidently segmented core, and those with a vaguely segmented or missing core. Since by assumption every tumor has a core, we reduce the threshold for classification of core tissue in those cases where the core, as segmented by the classifier, is vaguely defined or missing. We then predict survival of high-grade glioma patients using a fusion of linear regression and random forest classification, based on age, number of distinct tumor components, and number of distinct tumor cores. We present results on the validation dataset of the Multimodal Brain Tumor Segmentation Challenge 2020 (segmentation and uncertainty challenge), and on the testing set, where the method achieved 4th place in Segmentation, 1st place in uncertainty estimation, and 1st place in Survival prediction.