论文标题

在动态网络中对同质性进行建模,并应用于HIV分子监测

Modeling Homophily in Dynamic Networks with Application to HIV Molecular Surveillance

论文作者

DeGruttola, V., Nakazawa, M., Liu, J., Tu, X., Little, S., Mehta, S.

论文摘要

本文描述了一种新颖的方法来建模与人类的建模,即共享(或不同)某些属性的节点的趋势;我们考虑动态网络,其中可以随着时间的推移而添加节点,但不会删除节点。我们的应用是用于研究HIV传播动态的HIV遗传连锁分析。在这种情况下,如果这些序列之间的遗传距离小于给定的阈值,则据说来自不同HIV(PWH)的两个HIV序列是联系的。这种联系表明,代表两个感染PWH的节点在传输网络中彼此接近。这种接近性意味着,一个被感染的人中的一个直接传播到病毒,或间接通过少数中介机构传播。这些病毒遗传连锁网络是动态的,因为随着时间的流逝,由于新人直接或通过中间体被群集感染了新人,因此大小或遗传连接的病毒序列可能会增加。我们的方法利用了逻辑模型来描述同质性的人口统计学和行为特征,我们研究了这些特征中PWH之间的相似性(或差异)是否会影响其序列链接的概率。此类分析提供了有关人群中HIV传播动态的信息。

This paper describes a novel approach to modeling homphily, i.e. the tendency of nodes that share (or differ in) certain attributes to be linked; we consider dynamic networks in which nodes can be added over time but not removed. Our application is to HIV genetic linkage analysis that has been used to investigate HIV transmission dynamics. In this setting, two HIV sequences from different persons with HIV (PWH) are said to be linked if the genetic distance between these sequences is less than a given threshold. Such linkage suggests that that the nodes representing the two infected PWH, are close to each other in a transmission network; such proximity would imply that either one of the infected people directly transmitted the virus to the other or indirectly transmitted it through a small number of intermediaries. These viral genetic linkage networks are dynamic in the sense that, over time, a group or cluster of genetically linked viral sequences may increase in size as new people are infected by those in the cluster either directly or through intermediaries. Our approach makes use of a logistic model to describe homophily with regard to demographic and behavioral characteristics that is we investigate whether similarities (or differences) between PWH in these characteristics impacts the probability that their sequences are be linked. Such analyses provide information about HIV transmission dynamics within a population.

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