论文标题
Fontan循环的最佳散剧
Optimal fenestration of the Fontan circulation
论文作者
论文摘要
在本文中，我们开发了Fontan循环的脉动隔室模型，并使用它来探索延伸添加到该生理学的效果。 Fenreatation是全身性和肺静脉之间的分流器，在Fontan转化时或以后的并发症治疗时添加。该分流会增加心输出量并降低全身静脉压力。但是，这些血液动力学益处是以减少动脉氧饱和度减少的代价。该模型开发了本文，将Fenreatration尺寸作为参数，并描述了血流和氧运输。它被校准了Fontan患者的临床数据，我们使用它来研究塞术对几种血液动力学变量的影响。在某些对应于高风险丰坦生理学的情况下，我们证明了最佳塞式大小的存在，从而最大程度地递送了氧气向全身组织。
In this paper, we develop a pulsatile compartmental model of the Fontan circulation and use it to explore the effects of a fenestration added to this physiology. A fenestration is a shunt between the systemic and pulmonary veins that is added either at the time of Fontan conversion or at a later time for the treatment of complications. This shunt increases cardiac output and decreases systemic venous pressure. However, these hemodynamic benefits are achieved at the expense of a decrease in the arterial oxygen saturation. The model developed this paper incorporates fenestration size as a parameter and describes both blood flow and oxygen transport. It is calibrated to clinical data from Fontan patients, and we use it to study the impact of a fenestration on several hemodynamic variables. In certain scenarios corresponding to high-risk Fontan physiology, we demonstrate the existence of an optimal fenestration size that maximizes oxygen delivery to the systemic tissues.
