论文标题
示踪剂颗粒在不影响癌细胞的异常动力学的情况下感知不断发展的多细胞球体中的局部应力
Tracer particles sense local stresses in an evolving multicellular spheroid without affecting the anomalous dynamics of the cancer cells
论文作者
论文摘要
通过将惰性可压缩示踪剂颗粒（TPS）嵌入生长的多细胞球体（MCS）中推断出的癌细胞（CCS）的局部应力测量，表明压力随着与MCS核心的距离的增加而单调降低。 TPS报告如何忠实地报告CCS中的局部应力是一个重要的问题，因为由于CC分裂，MCS中的压力积累是动态产生的，这意味着CC动力学应由TPS最小化。在这里使用理论和模拟，我们表明，尽管TP动力学是不寻常的，但在长期限制中表现出少于CC分裂时间的次序行为，但它们不会影响长期的CC Dynamics或局部CC应力分布。 MC中的CC压力曲线从核心处的高值衰减到外围，几乎与TPS相同。 TPS对MC中的局部应力具有微不足道的影响，这意味着它们是CC微环境的可靠记者。
Measurements of local stresses on the cancer cells (CCs), inferred by embedding inert compressible tracer particles (TPs) in a growing multicellular spheroid (MCS), show that pressure decreases monotonically as the distance from the core of the MCS increases. How faithfully do the TPs report the local stresses in the CCs is an important question because pressure buildup in the MCS is dynamically generated due to CC division, which implies that the CC dynamics should be minimally altered by the TPs. Here using theory and simulations, we show that although the TP dynamics is unusual, exhibiting sub-diffusive behavior on times less than the CC division times and hyper-diffusive dynamics on in the long-time limit, they do not affect the long-time CC dynamics or the local CC stress distributions. The CC pressure profile within the MCS, which decays from a high value at the core to the periphery, is almost identical with and without the TPs. That the TPs have insignificant effect on the local stresses in the MCS implies that they are reliable reporters of the CC microenvironment.
