论文标题
早期脊椎动物胚胎发生中Wnt信号传导的数学建模肖像
A mathematical modelling portrait of Wnt signalling in early vertebrate embryogenesis
论文作者
论文摘要
在早期脊椎动物的胚胎发生中，Wnt信号传导有两个阶段：非常早，母体Wnt信号传导促进背发育，稍后，滞后Wnt信号促进腹侧和侧端中胚层诱导。然而，最近的分子生物学分析揭示了至少五个类别的直接Wnt靶基因之间的复杂性。在这里，为了测试这些发现所建议的新基因调节网络模型的逻辑和动力学，我们使用基于普通微分方程（ODE）的数学建模。我们对该基因调节网络的数学建模表明，一个简化的模型，每个类别的“超基因”在很大程度上足以描述先前在实验中观察到的调节行为。
There are two phases of Wnt signalling in early vertebrate embryogenesis: very early, maternal Wnt signalling promotes dorsal development, and slightly later, zygotic Wnt signalling promotes ventral and lateral mesoderm induction. However, recent molecular biology analysis has revealed more complexity among the direct Wnt target genes, with at least five classes. Here in order to test the logic and the dynamics of a new Gene Regulatory Network model suggested by these discoveries we use mathematical modelling based on ordinary differential equations (ODEs). Our mathematical modelling of this Gene Regulatory Network reveals that a simplified model, with one "super-gene" for each class is sufficient to a large extent to describe the regulatory behaviour previously observed experimentally.
