论文标题
二进制力学模型系统的力学，能量，熵和动力学
Mechanics, Energetics, Entropy and Kinetics of a Binary Mechanical Model System
论文作者
论文摘要
随着热力学弹簧的形式构造，我描述了二进制力学模型系统的力学，能量，熵和动力学。在两个亚稳态结构态之间过渡的蛋白质表现为分子开关，而分子开关的集合可以取代用系统力平衡的兼容元素构成二进制机械模型系统。在生物系统中，许多蛋白质开关与细胞力平衡，但是与该系统相关的统计机械问题仍未解决。二元力学模型系统建立了有限数量的宏观参数，必须拟合结构和机械细节。新的进步包括非平衡动力学和能量等效性。动力学和能量学的可扩展限制；以及对动力学和力学的熵影响。该模型统一了分子运动机械化学的不同模型，解释了瞬态和稳态肌肉的机械性能，并为生物力学提供了新的视角，重点是这里肌肉和分子运动集合的工作方式。
With the formal construction of a thermodynamic spring, I describe the mechanics, energetics, entropy, and kinetics of a binary mechanical model system. A protein that transitions between two metastable structural states behaves as a molecular switch, and an ensemble of molecular switches that displace compliant elements equilibrated with a system force constitutes a binary mechanical model system. In biological systems, many protein switches equilibrate with cellular forces, yet the statistical mechanical problem relevant to this system has remained unsolved. A binary mechanical model system establishes a limited number of macroscopic parameters into which structural and mechanistic details must be fit. Novel advances include a non-equilibrium kinetic and energetic equivalence; scalable limits on kinetics and energetics; and entropic effects on kinetics and mechanics. The model unifies disparate models of molecular motor mechanochemistry, accounts for the mechanical performance of muscle in both transient and steady states, and provides a new perspective on biomechanics with a focus here on how muscle and molecular motor ensembles work.
