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The precision cosmological model describing the origin and expansion history of the universe, with observed structure seeded at the inflationary cosmic horizon, demands completion in the ultraviolet and in the infrared. The dynamics of the cosmic horizon also suggests an associated entropy, again requiring a microphysical theory. Recent years have seen enormous progress in understanding the structure of de Sitter space and inflation in string theory, and of cosmological observables captured by quantum field theory and solvable deformations thereof. The resulting models admit ongoing observational tests through measurements of the cosmic microwave background and large-scale structure, as well as through analyses of theoretical consistency by means of thought experiments. This paper, prepared for the TF01 and TF09 conveners of the Snowmass 2021 process, provides a synopsis of this important area, focusing on ongoing developments and opportunities.