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Architectures for quantum computing based on neutral atoms have risen to prominence as candidates for both near and long-term applications. These devices are particularly well suited to solve independent set problems, as the combinatorial constraints can be naturally encoded in the low-energy Hilbert space due to the Rydberg blockade mechanism. Here, we approach this connection with a focus on a particular device architecture and explore the ubiquity and utility of independent set problems by providing examples of real-world applications. After a pedagogical introduction of basic graph theory concepts of relevance, we briefly discuss how to encode independent set problems in Rydberg Hamiltonians. We then outline the major classes of independent set problems and include associated example applications with industry and social relevance. We determine a wide range of sectors that could benefit from efficient solutions of independent set problems -- from telecommunications and logistics to finance and strategic planning -- and display some general strategies for efficient problem encoding and implementation on neutral-atom platforms.