论文标题
在241am alpha颗粒的轨道结构中两个空间分离的纳米体积中的相关电离：与蒙特卡罗模拟的比较
Correlated ionisations in two spatially separated nanometric volumes in the track structure of 241Am alpha particles: comparison with Monte Carlo simulations
论文作者
论文摘要
在DNA分子上的空间分离位置中产生两个双链断裂可能会导致整个DNA环的损失，这可能长度长，具体取决于两个受损位点的几何位置，并取决于在大小尺寸的几个纳米米的位点形成的电离簇之间的相关程度。在本文的第一部分中，据报道，据报道，据报道，据报道，有PTB离子计数器纳米二轴测表的1.2 MBAR H2O，1.2 MBAR C3H8和1.2 MBAR C4H8O的α粒子轨迹的纳米光度测量。在第二部分中，重点是在三个目标气体中使用纳米仪模拟的两个位点的几何表征以及测量结果与蒙特卡洛模拟的比较。用轨道结构代码PTRA的版本模拟了1.2 MBAR C3H8中的测量值，该版本用于对PTB ION计数器纳米尺度表进行建模。用Geant4-DNA进行进一步的模拟，以在241am alpha粒子轨道中进行液体水。发现测量和实际测量结果的模拟对于所研究的辐射几何形状非常吻合。
The production of two double strand breaks in spatially separated locations on the DNA molecule can cause the loss of a whole DNA loop, which can be of substantial length depending on the geometrical position of the two damaged sites and depends on the degree of correlation between ionisation clusters formed in sites of several nanometres in size. In the first part of this paper, nanodosimetric measurements of alpha particle tracks in 1.2 mbar H2O, 1.2 mbar C3H8 and 1.2 mbar C4H8O with the PTB ion counter nanodosimeter were reported. In this second part, the focus is on the geometrical characterisation of the two sites simulated with the nanodosimeter in the three target gases and on the comparison of the measurement results with Monte Carlo simulations. The measurements in 1.2 mbar C3H8 were simulated with a version of the track structure code PTra dedicated to modelling the PTB ion counter nanodosimeter. Further simulations were performed with Geant4-DNA for 241Am alpha particle tracks in liquid water. Simulations of the measurements and the actual measurement results are found to be in good agreement for the investigated irradiation geometries.
