论文标题
使用有限元法估算硼在质子治疗中的治疗应用粒径
Estimating Particle Size for Therapeutic Application of Boron in Proton Therapy using the Finite Element Method
论文作者
论文摘要
先前的测量结果显示了11B（P，$α$）8BE反应和H+离子的硼离子化的大横截面。过去的出版物表明，这种反应可能会提高质子治疗的功效。这项研究研究了硼颗粒的大小，以增强质子治疗的最佳治疗。开发了穿过各种大小的硼颗粒的质子的模拟，以比较α颗粒和低能电子的能量输出。产生最大辐射输出的硼颗粒半径的结果以图形形式表示。产生最大螺旋钻输出的半径确定为1.3 nm。结果表明，最大剂量增强将取决于生物系统在适当尺寸的粒子方面的限制因子。研究可以在强子疗法中应用的不同反应，可以使研究人员和医生更有选择地针对肿瘤部位。
Previous measurements have shown large cross sections for the 11B(p,$α$)8Be reaction and K-shell ionization of boron from H+ ions. Past publications have shown that this reaction will likely increase the efficacy of proton therapy. This study investigates the size of boron particles for optimum treatment enhancement in proton therapy. Simulations of protons passing through varying sized boron particles were developed to compare energy outputs for alpha particles and low energy electrons. The results for the boron particle radius that produced the largest radiation output are presented in graphical form in this paper. The radius that produced the largest Auger output was determined to be 1.3 nm. The results indicate that maximum dose enhancement will depend on the limiting factors of the biological system in regards to the appropriately sized particle. Studying different reactions that may be applied in hadron therapies allows researchers and physicians to target tumor sites more selectively.
