论文标题
钙粘蛋白簇在细胞细胞界面上的成核
Nucleation of cadherin clusters on cell-cell interfaces
论文作者
论文摘要
钙粘蛋白介导细胞 - 细胞粘附并帮助细胞确定其形状和功能。在这里，我们研究了细胞 - 细胞接触区域内的集体钙粘蛋白组织和相互作用，并找到钙粘着蛋白的密度，当时发生气体相过渡的钙粘蛋白，当钙粘蛋白单体开始聚集成密集的簇时。我们使用细胞 - 细胞接触区域的2D晶格模型，而粗粒到钙粘着蛋白的连续数密度，以将模型映射到Cahn-Hilliard的粗化理论上。这可以预测成核所需的密度，过程的特征长度尺度以及簇的数量密度。该模型的分析预测与上皮组织中钙粘蛋白聚类的实验性观察非常吻合。
Cadherins mediate cell-cell adhesion and help the cell determine its shape and function. Here we study collective cadherin organization and interactions within cell-cell contact areas, and find the cadherin density at which a gas-liquid phase transition occurs, when cadherin monomers begin to aggregate into dense clusters. We use a 2D lattice model of a cell-cell contact area, and coarse-grain to the continuous number density of cadherin to map the model onto the Cahn-Hilliard coarsening theory. This predicts the density required for nucleation, the characteristic length scale of the process, and the number density of clusters. The analytical predictions of the model are in good agreement with experimental observations of cadherin clustering in epithelial tissues.
