论文标题
可逆组织电穿孔及其在药物输送中的热效应的建模
Modelling of reversible tissue electroporation and its thermal effects in drug delivery
论文作者
论文摘要
电穿孔是将药物输送到人体各种患病组织中的非常有用的工具。该技术通过迅速将药物转移到靶细胞中来改善临床治疗。在电穿孔中，由于施加的电场，药物颗粒通过临时通透的细胞膜轻松进入细胞内室。在这项工作中，提出了一个针对可逆组织电穿孔的药物输送的数学模型。另外，还考虑了对组织的热作用，这是焦耳加热的结果。该模型引入了时间依赖的传质系数，这对药物转运很重要。使用低压的多个脉冲可用于将足够的药物吸入靶细胞。根据物理情况，考虑并解决了一组微分方程。分析了不同参数（例如扩散系数，药物渗透率，脉冲长度和脉搏数）的药物浓度变化。该模型可优化电穿孔参数，以充分吸收没有热损伤的细胞中。该模型可以在临床实验中使用，以根据感染的性质控制模型参数来预测药物对感染细胞的摄取。
Electroporation is a very useful tool for drug delivery into various diseased tissues of the human body. This technique helps to improve the clinical treatment by transferring drugs into the targeted cells rapidly. In electroporation, drug particles enter easily into the intracellular compartment through the temporarily permeabilized cell membrane due to the applied electric field. In this work, a mathematical model of drug delivery focusing on reversible tissue electroporation is presented. In addition, the thermal effects on the tissue, which is an outcome of Joule heating, are also considered. This model introduces a time-dependent mass transfer coefficient, which is significant to drug transport. Multiple pulses with low voltage are applied to reach sufficient drugs into the targeted cells. According to the physical circumstances, a set of differential equations are considered and solved. The changes in drug concentration with different parameters (e.g., diffusion coefficient, drug permeability, pulse length, and pulse number) are analyzed. The model optimizes the electroporation parameters to uptake drugs sufficiently into the cells with no thermal damage. This model can be used in clinical experiments to predict drug uptake into the infected cells by controlling the model parameters according to the nature of infections.
