论文标题
肌无力的疗程诊断为表面增强的拉曼光谱法
Myasthenia Gravis Diagnosis with Surface-enhanced Raman Spectroscopy
论文作者
论文摘要
这项研究调查了表面增强的拉曼光谱法（SER）作为肌无力的肌无力的诊断工具，肌无力是一种严重的神经肌肉疾病，其特征是肌肉无力和疲劳。使用嵌入5 nm金纳米颗粒的SERS底物分析血清样品，从而导致明显的拉曼信号增强和检测疾病特异性光谱特征。该研究表明，SERS确定与氧化应激相关的细微生化变化和血清中分子组成改变的潜力，从而提供了一种敏感且无创的诊断方法。
This study investigates the application of surface-enhanced Raman spectroscopy (SERS) as a diagnostic tool for myasthenia gravis, a severe neuromuscular disorder characterized by muscle weakness and fatigue. Blood serum samples were analyzed using SERS substrates embedded with 5 nm gold nanoparticles, resulting in significant Raman signal enhancement and the detection of disease-specific spectral features. The study demonstrates the potential of SERS to identify subtle biochemical changes associated with oxidative stress and altered molecular composition in serum, providing a sensitive and non-invasive approach for diagnosis.
