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Mode-locked lasers play a key role in modern science and technology. Not only do they lay the foundation for ultrafast optics and play a central role in nonlinear optics, but also they have important applications in imaging, telecommunications, sensing, and computing. While substantial efforts have focused on mode-locking the spectral modes of lasers, relatively little attention has been paid to mode-locking their temporal modes. However, temporal mode-locking presents ample opportunities to develop new technologies and to study the intersection of nonlinear, non-Hermitian, and topological phenomena, which, in recent years, has been a priority for the field of topological physics. Here, we theoretically predict and experimentally realize topological temporal mode-locking in a laser cavity with time-delayed intracavity couplings. These couplings introduce non-Hermitian point-gap topology into the temporal modes of our laser and conspire with an effective nonlocal nonlinearity to generate mode-locked temporal structures in our laser cavity, whose form can be tailored by suitably engineering the underlying couplings. We harness this approach to realize a nonlinearity-driven non-Hermitian skin effect, and we show that the topological temporal modes of our laser are robust against disorder-induced localization. The flexibility and programmability of our topological temporal mode-locking scheme reveals new opportunities to study nonlinear and non-Hermitian topological phenomena in mode-locked photonic resonators and could enable new applications of mode-locked lasers to sensing and optical computing.