论文标题
酒精的摄入量会区分广告和迟到：两个大规模数据集的讲故事的生活方式
Alcohol Intake Differentiates AD and LATE: A Telltale Lifestyle from Two Large-Scale Datasets
论文作者
论文摘要
阿尔茨海默氏病（AD）作为一种进行性脑部疾病，会影响认知，记忆和行为。同样，边缘促销与年龄相关的TDP-43脑病（晚）是一种最近定义的常见神经退行性疾病，模仿了AD的临床症状。目前，涉及后期和与AD的较晚的风险因素在很大程度上未知。我们利用了一种基于特征选择的算法方法，以确定与延迟和/或广告区分有关数据的重要因素的重要因素。我们分析了两个数据集Rosmap和NACC，并发现酒精消耗是与晚期和AD及其关联有关的最佳生活方式和环境因素。特别是，我们确定了由APOE E4载体组成的特定亚群。我们发现，对于这种亚种群，降至中度的酒精摄入量是抵抗AD和迟到的保护因素，但其对AD的保护作用似乎比晚更强大。我们的算法代码可在https://github.com/xinxingwu-uk/pfv上找到。
Alzheimer's disease (AD), as a progressive brain disease, affects cognition, memory, and behavior. Similarly, limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined common neurodegenerative disease that mimics the clinical symptoms of AD. At present, the risk factors implicated in LATE and those distinguishing LATE from AD are largely unknown. We leveraged an integrated feature selection-based algorithmic approach, to identify important factors differentiating subjects with LATE and/or AD from Control on significantly imbalanced data. We analyzed two datasets ROSMAP and NACC and discovered that alcohol consumption was a top lifestyle and environmental factor linked with LATE and AD and their associations were differential. In particular, we identified a specific subpopulation consisting of APOE e4 carriers. We found that, for this subpopulation, light-to-moderate alcohol intake was a protective factor against both AD and LATE, but its protective role against AD appeared stronger than LATE. The codes for our algorithms are available at https://github.com/xinxingwu-uk/PFV.
