论文标题
通过贝叶斯元学习的几乎没有发电的个性化神经替代物,用于心脏模拟
Few-shot Generation of Personalized Neural Surrogates for Cardiac Simulation via Bayesian Meta-Learning
论文作者
论文摘要
个性化虚拟心脏模拟的临床采用在模型个性化和昂贵的计算中面临挑战。虽然理想的解决方案是一种有效的神经代理,同时是个性化的,但最先进的是与个性化昂贵的仿真模型有关,或者学习有效但通用的代理。本文提出了一个全新的概念,可以在单一的元学习(Metapns)中实现个性化的神经替代物。 Instead of learning a single neural surrogate, we pursue the process of learning a personalized neural surrogate using a small amount of context data from a subject, in a novel formulation of few-shot generative modeling underpinned by: 1) a set-conditioned neural surrogate for cardiac simulation that, conditioned on subject-specific context data, learns to generate query simulations not included in the context set, and 2) a meta-model of amortized variational通过简单的上下文数据的简单馈送嵌入来调节神经替代物的推论。作为测试时间,Metapns通过快速馈送前向前的嵌入一个少量且灵活的数据可从个人获得的少量数据来提供个性化的神经代理,这是第一次实现个性化和代理构造,以在一端到端学习框架中昂贵的模拟。合成和真实数据实验表明,与常规优化的心脏仿真模型相比,MetaPN能够提高个性化和预测精度。
Clinical adoption of personalized virtual heart simulations faces challenges in model personalization and expensive computation. While an ideal solution is an efficient neural surrogate that at the same time is personalized to an individual subject, the state-of-the-art is either concerned with personalizing an expensive simulation model, or learning an efficient yet generic surrogate. This paper presents a completely new concept to achieve personalized neural surrogates in a single coherent framework of meta-learning (metaPNS). Instead of learning a single neural surrogate, we pursue the process of learning a personalized neural surrogate using a small amount of context data from a subject, in a novel formulation of few-shot generative modeling underpinned by: 1) a set-conditioned neural surrogate for cardiac simulation that, conditioned on subject-specific context data, learns to generate query simulations not included in the context set, and 2) a meta-model of amortized variational inference that learns to condition the neural surrogate via simple feed-forward embedding of context data. As test time, metaPNS delivers a personalized neural surrogate by fast feed-forward embedding of a small and flexible number of data available from an individual, achieving -- for the first time -- personalization and surrogate construction for expensive simulations in one end-to-end learning framework. Synthetic and real-data experiments demonstrated that metaPNS was able to improve personalization and predictive accuracy in comparison to conventionally-optimized cardiac simulation models, at a fraction of computation.