论文标题
对反应性高血症进行建模以更好地理解和评估微血管功能：综述技术
Modeling Reactive Hyperemia to better understand and assess Microvascular Function: a review of techniques
论文作者
论文摘要
反应性充血是一种公认的技术，用于对外围微循环功能的非侵入性评估，在短暂的缺血后，被视为肢体再灌注的大小。尽管研究人员和临床医生都广泛采用，但许多不确定性仍然围绕着解释，这是患者特定的混杂因素（例如血压或缺血性肢体的代谢率）更加复杂的。数学建模可以加速我们对反应性充血反应背后的生理学的理解，并指导估计数量难以在实验中测量的数量。在这项工作中，我们旨在为数学建模技术提供综合指南，该指南可用于描述反应性充血反应中涉及的关键现象，以及它们的局限性和优势。报告的方法可用于单独研究特定的反应性充血方面，也可以将其合并到用于（前）临床环境中的计算框架中。
Reactive hyperemia is a well-established technique for the non-invasive evaluation of the peripheral microcirculatory function, measured as the magnitude of limb re-perfusion after a brief period of ischemia. Despite widespread adoption by researchers and clinicians alike, many uncertainties remain surrounding interpretation, compounded by patient-specific confounding factors (such as blood pressure or the metabolic rate of the ischemic limb). Mathematical modeling can accelerate our understanding of the physiology underlying the reactive hyperemia response and guide in the estimation of quantities which are difficult to measure experimentally. In this work, we aim to provide a comprehensive guide for mathematical modeling techniques that can be used for describing the key phenomena involved in the reactive hyperemia response, alongside their limitations and advantages. The reported methodologies can be used for investigating specific reactive hyperemia aspects alone, or can be combined into a computational framework to be used in (pre-)clinical settings.
