论文标题

实验室规模连续搅拌罐反应堆的建模和经济最佳控制,用于单细胞蛋白

Modelling and Economic Optimal Control for a Laboratory-scale Continuous Stirred Tank Reactor for Single-cell Protein Production

论文作者

Nielsen, Marcus Krogh, Dynesen, Jens, Dragheim, Jess, Christensen, Ib, Jørgensen, Sten Bay, Huusom, Jakob Kjøbsted, Gernaey, Krist V., Jørgensen, John Bagterp

论文摘要

在本文中,我们提出了一个新型的微生物\ textit {甲基环囊膜}(浴)的动力学生长模型,该模型将生长和pH结合在一起。我们将生长动力学应用于模型中,以在受物理实验室发酵罐启发的实验室尺度连续搅拌罐反应器中进行单细胞蛋白的产生。该模型包含一组描述系统中生长和pH动力学的差分代数方程。我们提出了一种模拟方法,该方法可确保状态和代数变量的非负性。此外,我们引入了代数方程的线性缩放和变量,以在牛顿方法中进行数值稳定性。最后,我们对实验室尺度反应堆中的单细胞蛋白质产生进行了经济最佳控制的数值实验。数值实验显示了用于生物量生长和pH跟踪的非平凡输入曲线。

In this paper, we present a novel kinetic growth model for the micro-organism \textit{Methylococcus capsulatus} (Bath) that couples growth and pH. We apply growth kinetics in a model for single-cell protein production in a laboratory-scale continuous stirred tank reactor inspired by a physical laboratory fermentor. The model contains a set of differential algebraic equations describing growth and pH-dynamics in the system. We present a method of simulation that ensures non-negativity in the state and algebraic variables. Additionally, we introduce linear scaling of the algebraic equations and variables for numerical stability in Newton's method. Finally, we conduct a numerical experiment of economic optimal control for single-cell protein production in the laboratory-scale reactor. The numerical experiment shows non-trivial input profiles for biomass growth and pH tracking.

扫码加入交流群

加入微信交流群

微信交流群二维码

扫码加入学术交流群,获取更多资源